Efficacia di acitretina nella psoriasi severa
Efficacy of Acitretin in Severe Psoriasis J.M. Geiger, MD, Pharm D (Université Louis Pasteur, Strasburg, France) Acitretin (SORIATANE Ò , Roche Pharmaceuticals) is an aromatic retinoid, effective in the treatment of severe psoriasis. This study highlights data from two existing clinical trials to capture PASI 50 and PSI 75 responder rates which represent a common metric used in current psoriasis clinical trials. A review of pharmacokinetics, safety and a discussion of relapse rate establish acitretin as an efficacious, convenient, oral treatment for initial and maintenance therapy of severe psoriasis. Key Words: acitretin, aromatic retinoid, psoriasis, PASI Versione in lingua originale: http://www.skintherapyletter.com/2003/8.4/1.html Acitretina (SORIATANE Ò ) è un retinoide aromatico utilizzato nel trattamento sintomatico della psoriasi di grado severo. Meccanismo di azione L’efficacia di acitretina nel trattamento della psoriasi è perlopiù spiegato dal fatt